Immune Defense does not contain any strains that are not resident to the human gut, like Soil Based Organisms (SBOs) or active yeasts

† At the time of manufacture.

A shelf life you can count on. We use a patented manufacturing process called LiveBac® that increases the stability of Immune Defense without refrigeration and enables us to guarantee its shelf life until the date of expiration found on the bottom of your bottle.

Store in a cool, dry place. Really. If you don't live in a cool, dry place or keep your home below 78 degrees, it is best to store your bottle in the fridge or even better, in the freezer, when/if you can. Immune Defense is only susceptible to extreme heat and humidity once the bottle has been opened (our probiotics are very well protected until then). Immune Defense has a guaranteed, extended shelf life with zero refrigeration.

Use earlier rather than later. The reason we never have too many tablets per bottle at Hyperbiotics is that CFUs begin to slowly die off once the bottle is opened (this applies to all probiotics, not just Immune Defense. In fact, our patented technology makes our die-off drastically slower than that of others!). We want you to get the highest potency possible, so we simply don't pack hundreds of tablets into one bottle.

Increase your dosage when needed. If you are looking for a more intense approach to probiotic supplementation and immune support, you can take 2-3 tablets each day. It's also a good idea to increase your dosage just before and during travel, as it often exposes you to added digestive and immune stress.

Recycle your bottle when you're done. We're committed to minimizing our ecological footprint, and we'd love for you to join us by recycling your empty bottle whenever possible. In fact, we're taking action to reduce negative impacts on our planet's natural resources and improve ecosystems around the world.

An additional tip is to eat a whole food diet high in fruits and vegetables and to supplement with Prebiotic Powder. Studies indicate that the microorganisms in our gut change relatively quickly based on the food we eat. Foods that are rich in prebiotics will also help your probiotics colonize and “set up shop” in your GI tract. It's difficult to get all the prebiotic fiber you need as part of your daily diet, though––which is why we recommend supplementing with a scoop of Prebiotic Powder every day.

When you combine a clean, whole food diet with probiotic and prebiotic supplementation, you are giving your body the tools it needs to find its balance again. Make sure to stay hydrated and to stay as active as you can so that your body can move out the unnecessary as your probiotic colonies are being repopulated.

What strains are in Immune Defense?
Immune Defense contains the following probiotic strains:
• Lactobacillus plantarum HEAL9
• Lactobacillus paracasei 8700:2

What are the benefits of taking probiotics?
Probiotics replenish the good bacteria in your gut and help keep you healthy by:
• Supporting your immune function 
• Maintaining your overall health
• Helping to reduce the frequency, severity, and duration of respiratory tract issues
• Supporting vitality and well-being

What makes Hyperbiotics probiotics premium?
Our formulas meet these four criteria:
• Survival on the shelf
• Survival past stomach acid
• The right strains (human resident strains as opposed to SBOs or active yeasts)
• A variety of strains

How quickly can I expect to feel a difference?
Probiotics are much like vitamins, some people notice a difference almost immediately, while others may need a few weeks or more. It’s also possible to simply notice a subtle shift in a healthier direction. From the day you start taking Immune Defense, it gets to work colonizing in your digestive tract

Why don’t the probiotics in Immune Defense need BIO-tract® protection?

The two strains in Immune Defense, Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2, are incredibly robust and have been clinically studied to support a healthy immune system in a daily chewable tablet. Unlike the vast majority of probiotics, because of their hardy nature, these unique organisms don’t require BIO-tract® protection.

How should I take Immune Defense?
With a yummy natural orange flavor, Immune Defense is formulated to be chewed or dissolved in the mouth. And don’t worry, chewing won’t damage these hardy probiotics! Meant to colonize deep within the gut, the organisms in this formula have been clinically studied to support a healthy immune system in a daily chewable tablet without patented BIO-tract® protection.

How long should I take a probiotic?
We believe that taking a probiotic on a daily basis is one of the most proactive things that you can do to support your immune and digestive health. Because aspects of modern life can continuously deplete the beneficial bacteria in the gut, we suggest taking probiotics daily over the course of several months or more.

Do I need to refrigerate these?
With patented LiveBac®, we are able to guarantee our formulas with zero refrigeration—so you can be confident that your probiotics are viable when you take them.

Will my probiotics survive being shipped in the heat?
Yes! LiveBac® enables our products to withstand extreme heat for up to 7 days—even longer if both seals are left intact.

Need help understanding the microbiome?
Check out our Microbiome Glossary to learn more about this world beneath the microscope.

Have additional questions? We’ve got answers! View our complete FAQ list here!

• Continental U.S. orders: We offer FREE standard shipping on all continental U.S. orders over $39, which takes 1 business day for processing and 2-7 business days for shipping. We also offer FREE expedited shipping for orders over $100. If your order is less than $100, you can choose expedited shipping for $8. Expedited shipping takes 1 business day for processing and 2-5 business days for shipping.

• All other U.S. orders (HI, AK, U.S. territories, and APO addresses): We offer FREE standard shipping for orders over $45. If your order is less than $45, you can choose standard shipping for $5. Standard shipping takes 1 business day for processing and 3-7 business days for shipping. We also offer FREE expedited shipping for orders over $100. If your order is less than $100, you can choose expedited shipping for $8. Expedited shipping takes 1 business day for processing and 2-6 business days for shipping.

• International Orders (outside of the USA): We offer a flat fee of $10 to the countries listed below. For countries not on the list, we can ship via USPS or DHL and the cost varies by country. Please note we are not responsible for duties, taxes, or customs clearance in your country. Please check your local requirements before placing your order.

We offer a 100% Satisfaction Guarantee or your money back!

"They really did feel like they made a difference compared to other probiotic supplements I've tried. Felt more regular and less stomach discomfort without changing any other dietary habits. Definitely worth a try if you have stomach issues and tried other supplements but felt little difference. I also like the little "pill" since I sometimes find it harder to swallow capsules." - SJ

"I've been taking it for about a month and I have noticed a significant difference in my energy level during the day and I'm sleeping better. I like it so much, I added it to my monthly auto-ship order." - Amazon Customer

"I am loving this product! Due to assorted demands on my time, I have had only 5 or 6 hours of sleep per night for over two weeks now, and still have been able to maintain my energy and health. Normally I would be a complete mess by now. The only thing that I am doing different, and thus the only explanation that I can give, is that I had just started taking this product twice a day. It's miraculous. Hopefully I will be able to get back to a normal sleep schedule soon, but meanwhile I am overjoyed to know that I can still function under stress with Pro-15. Great product! Thank you!" - Amazon Customer

"I have now been taking for about 15 days and this is by far the best probiotic for me. Everyone is different and I have tried at least 12-14 other brands with some being more effective than others, but nothing as good as this. This will be my go to brand for probiotics from here out." - Amazon Customer

"Very pleased with this product. I had not been able to eat gluten wheat products for a year. I took this probiotic for a month and the following month noticed that I wasn't becoming bloated after every meal. I experimented by eating foods that previously caused severe bloating and found that they didn't have that effect anymore. I did not take anymore after the first month, but after a few months noticed some symptoms returning and have begun to take these probiotics again. I have also recommended this brand to friends and they've also reported very good effect with it. Would continue to use this product and highly recommend it to others.

"I am an 85 yr. old female who has been searching for an effective probiotic since I suffer from chronic constipation due to necessary medications. And this IS IT."  - Amazon Customer

"It seems like I have tried everything--numerous brands of probiotics, exercise, stress reduction techniques, you name it. In addition to feeling crummy much of the time, I could never predict the stomach bloating. As an active person who is physically fit, I mostly wear loose fitting clothes because of the bloating. Finally, I found Hyperbiotics Probiotics and life is incredible. After reading about the process behind Hyperbiotics Probiotics I decided to give it a try. After just a few days, I have NEVER felt better--no more bloating and I feel great. At first I thought the results would be short lived, but after a month I couldn't be happier." -Connie W.

"I was actually deeply surprised at how well and how quickly this product worked. Resolved digestive issues following a long bout of antibiotics - and with that resolution came better energy, better mood, better skin. I was seriously skeptical of such broad claims; imagine my surprise when I find them to be valid, especially after trying other brands of probiotic without appreciable results. I couldn't be happier to be proved wrong." - Amazon Customer

"This is the only probiotic I'll ever use. I have a very sensitive stomach that usually always gives me problems but taking this has helped in so many ways, no longer feel or look bloated, no gas, and no more pain when food is digesting. I've taken other probiotics but this one out shines them all." - Alli

"I have been going thru various probiotics for a long time now, at least 4 different brands in the last 2.5 years. This works wonderfully and I was surprised at how quickly it started too. This is my third order. I waited until I had tried it for a few months before I decided to comment on its effect. It started working pretty quickly. I started taking one in the morning and one in the afternoon and things started improving, if you know what I mean. I then switched to two in the morning, on an empty stomach, and things got very well indeed. I will never give up this product." - Richard B.

"I just got this product this month. I noticed a change by the third day. By seventh day I no longer had any abdominal distress. I have normal digestive health back after decades of struggling. I could not be happier with my decision to try this little pill.

"It must be true what they say about it surviving the stomach and it's acids (reason it is so hard and compact), to then dissolve in gut and regulate your bowel." - S.Y. Townsend

"Just my personal experience. If there is a miracle pill then this is the one. Had digestion problems for years. Finally decided to try probiotics and purchased this product. Started with 2 pills a day - one in the morning and one in the afternoon. I started seeing very positive results within 3-4 days and I didn't change my diet. I continue taking 2 pills a day for about a month now. And just purchased 2 more bottles of this product." - NJ Vlad

"So far so good. Because of lifelong issues I have unfortunately had to practically live on antibiotics and I love the ease of taking these for my insides and even my skin. I feel better. Thank you! I'm sure I will be recommending it to others and continue using it." - Kathleen D.

"Your product has helped me so much. I'm a customer for life. I even turned some people at my job on to PRO-15 and they are loving it. I believe everyone should know about great products especially those that help change people's lives. Thank you again." - Brian S.

"Thank you all for making such a great product that REALLY WORKS!! I don't feel super tired anymore and my thoughts are much clearer. I thank you all for being a company that truly cares about the well being of others and sharing that care by making a product that helps to repair the daily damage that we do to our precious bodies.

"Every chance I get, I will spread the word about how awesome your probiotic is. I wish you all continued success!" - Donella H.

"We have been purchasing the PRO-15 probiotics for about a year and a half now. They work great for my wife's challenging digestive issue. Your product has been nothing short of spectacular for her. We went from her having issues almost daily, to once a month if that much. An extra pill calms the issue almost immediately." - Dawn C.

"I have had an array of stomach issues for as long as I can remember. After 4 days of using PRO-15 my symptoms started to go away and about a week into using it I said to my husband, "do you realize I haven't complained about my stomach in almost a week!"...life changing. I was suffering from insomnia and now I'm also sleeping through the night again! I mean it's been wonderful." - Mia Lyttle

"I love my Hyperbiotics! I was having tummy issues for awhile- typically a growling, exploding tummy in the afternoons after lunch. After a couple of weeks taking one daily pill, my issues cleared up. I've now been taking them for about 2 years, and I'm convinced that they keep my tummy much happier than it was before. If I'm feeling out of sorts, I'll take two pills in the morning instead of 1." - Eshell

"This product changed my life. I take one in the morning and one at night. No more distress. I had bloating so bad there were times I could not catch my breath. It would go on for hours. I feel better all the way around. I am a believer. I would recommend Hyperbiotics for anyone who wants to feel good." - CR Fadden

"Not every body is the same, but within 2 days this probiotic relieved all my issues with bloating and gas. I could never eat a big salad and then just go about my day... it was always something I'd have to eat late in the day knowing I'd be home the rest of the evening. I just wish I tried this sooner. I was having persistent bloating issues with or without eating a lot of vegetables. Not only does bloating make you uncomfortable in your own skin (and clothes), but it really affects your quality-of-life and willingness to want to go anywhere or do anything. I've taken other quality probiotics before, but this was the only one that truly worked for me." - LK

"I have been experimenting with probiotics for several years and although I hoped they made a difference, it was just faith. Then at the recommendation of a friend I tried PRO-15 and immediately felt the difference. More energy, no bloating, no gas, no indigestion. More importantly they don't require refrigeration and this is important because I travel constantly and can take it with me. I thought it was just a fluke but it is still working 6 months later. I am sticking with this and love it." - Dallas

"I can't believe how great this works! I read the reviews, wondering if you could possibly see a change in the way your body reacts to a probiotic so quickly. ( That had never been my experience in the past.) However, I must say I could tell a difference within a couple of days- no more bloated feeling, less gas, and less heartburn. After using it almost three weeks now, I can see even more difference. I am just getting ready to order my second bottle. This is a keeper!!!!" - M. Judy

"I really like these. I have been taking probiotics for years now following the recommendation of my naturopathic doctor and they had helped me so much initially that I stuck with them. Ever since my health had improved, though, I had never noticed a difference in energy or gut feeling no matter what brand I purchased...until these. They don't need refrigerated like most and are less expensive. Can't beat it!" - Nathan