Time Release Probiotics by Hyperbiotics® : 5 Billion CFU, 15 Strains, Lactobacillus, Bifidobacterium & Streptococcus


Time Released Pearls, Uniquely Formulated to Repopulate Your Gut

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  • GET 15 TIMES MORE SURVIVABILITY THAN WITH VEGGIE CAPSULES. With a patented delivery method, the probiotic organisms in this formula are released over an 8-10 hour period so they bypass your stomach acids and reach deep into your intestinal tract alive (where they are needed most) so you can experience the benefits that probiotics have to offer.

    STAY WELL. 80% of your immune system is in your gut. PRO-15 replenishes beneficial bacteria to support digestive and immune health. Life should be easy.

    SUPPORT YOUR WEIGHT MANAGEMENT EFFORTS. Did you know that scientists can predict body weight more effectively from a person's bacterial makeup (90 percent accuracy) than from their genes (58 percent accuracy)? It’s true. Studies suggest that gut flora may play a role in both metabolism and weight management.

    SUPPORT YOUR MOOD AND ENERGY LEVELS. PRO-15 helps create a microenvironment inside your digestive system that encourages nutrient absorption and may help you feel like your happy, energetic, and vibrant self.

    SENSITIVE STOMACH FRIENDLY. Unlike most probiotics, Hyperbiotics PRO-15 includes a patented time release delivery, meaning the beneficial bacteria are released at consistent levels throughout your Gl tract (versus all at once in your upper stomach). This delayed release can help reduce digestive upset.

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  • 15 Targeted Probiotic Strains (including Lactobacillus, Bifidobacterium, and Streptococcus) because bacterial diversity is key when it comes to gut health.

    Easy to Swallow. This tiny pearl is a fraction of the size of standard capsules. No wasted fillers, just micro-packed goodness. You’re welcome.

    Long Shelf Life & No Refrigeration Necessary. With the patented LiveBac® manufacturing process, we offer a guaranteed, extended shelf life with zero refrigeration. Many probiotics don't provide a date of any kind because their organisms die so quickly after being manufactured.

    Premium Probiotic Supplement. This formula is vegetarian, non-GMO, and free of dairy, gluten, and yeast. There is also no soy, sugar, nuts, artificial flavors, artificial colors, or preservatives.

    5 Billion Colony Forming Units per BIO-tract® pearl, which is equivalent to 75 Billion CFU (colony forming units) of standard probiotic capsules!

    Naturally Derived Prebiotic included in each pearl to help feed the probiotics for increased potency. Prebiotics are fibers that encourage the growth of beneficial bacteria throughout your colon.

    Only Once per Day. That's it. Because with time-release delivery, the benefits are being delivered deep inside your gut hour by hour.

    Made in the USA. Our probiotics are manufactured in Washington and Colorado in facilities that are GMP certified through NSF. We adhere to the strictest quality control and FDA guidelines and perform rigorous testing on every lot to ensure they are survivable and as the label states.

    PRO-15 does not contain any strains that are not resident to the human gut, like Soil Based Organisms (SBOs) or active yeasts.

    The Science Behind the Survivability

    Hyperbiotics PRO-15 Has 15x More Survivability Than Capsules.

    Let us explain…

    Probiotics help replenish the beneficial gut bacteria that may have been depleted as a result of modern life and they help support overall health and well-being.

    However, studies show that without protection most probiotics entering the stomach won't survive to reach optimal sites within the gastrointestinal tract. Most probiotic products retain only 4% of these sensitive organisms during passage through the stomach's harsh environment.

    The good news: with the patented BIO-tract® protection and time-release delivery, we have increased this number to a remarkable 60%.

    The BIO-tract® Difference

    When the tablet is moistened by gastric fluids, a gel matrix forms that creates a protective layer, shielding beneficial organisms from stomach acids and directing them to release later in their journey.

    Once inside the gastrointestinal tract, probiotics begin to release at consistent levels from the tablet core, delivering a potent percentage of our living organisms throughout the day and throughout your gut, traveling deep into your intestinal tract where they are needed most.

    This is the only controlled-release delivery available for probiotics on the market today and is patented in 31 countries (US Patent 8,007,777 and 7,150,623).

    BIO-tract® vs. Enteric Coated and Veggie Capsules

    Most probiotic supplements are in veggie capsules that offer no protection from a harsh stomach environment, meaning that many of the beneficial organisms do not survive long enough to deliver the full benefit.

    Enteric coated probiotic capsules offer some protection from stomach acids with a few drawbacks. Most enteric coatings are made of a synthetic chemical that the capsule is then dipped into. In addition to unwanted added chemicals, the capsule contains air and the coating contains moisture that may be detrimental to the probiotic organisms. You see, freeze-dried probiotic powder is ‘hygroscopic,’ meaning that it seeks out moisture. The beneficial flora will start wicking the moisture away from the air and the coating, which may start killing the living probiotics inside. Essentially, the air inside both veggie capsules and enteric coated capsules can cause the living organisms inside to self-destruct, leading to a far less potent product.

    Instead of a coating or a capsule, we tablet our formulas using a patented manufacturing process called LiveBac® and a patented delivery method called BIO-tract®, which provide protection for the beneficial flora while on the shelf (as there is minimal air and moisture) and as the tablet travels through the harsh environment of your stomach acids. Simply put, this leads to greater probiotic delivery to your gut, and potentially greater health benefits for you. Furthermore, BIO-tract® ensures that the active organisms are released slowly over an 8-10 hour period while making the journey through the intestinal tract, successfully bypassing your stomach acids so that they can colonize in your small and large intestine, where you need them.

    Hyperbiotics formulas have a guaranteed, extended shelf life with zero refrigeration.

    † At the time of manufacture.

    ‡ Patented BIO-tract® delivery method consistently delivers as many as 15 times, or more, the number of live, viable probiotic organisms past simulated stomach acids than veggie capsules as demonstrated through in vitro lab testing.

  • A shelf life you can count on. We use a patented manufacturing process called LiveBac® that increases the stability of PRO-15 without refrigeration and enables us to guarantee its shelf life until the date of expiration found on the bottom of your bottle.

    Store in a cool, dry place. Really. If you don’t live in a cool, dry place, it is best to store your bottle in the fridge or even better, in the freezer, when you can. This applies to any probiotic product – especially those in capsules or blister packs. With PRO-15, we guarantee the shelf life of our product with zero refrigeration – but, as a general rule, you will maximize the potency of any probiotic product by storing appropriately. And we are all about delivering the maximum effect!

    It’s OK to take on an empty stomach (though not required). Our patented BIO-tract® delivery process ensures that the vitamins and living organisms are delivered throughout your day and throughout your GI tract – so you don’t need to buffer it with food as you may with other capsules.

    Use earlier rather than later. The reason we never have too many tablets per bottle at Hyperbiotics is that CFUs begin to slowly die off once the bottle is opened (this applies to all probiotics, not just PRO-15. In fact, our patented technology makes our die-off drastically slower than that of others!). We want you to get the highest potency possible so we simply don't pack hundreds of tablets into one bottle.

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    Increase your dosage when needed. If you are in search of more intense support or have just completed a round of antibiotics, you can take 3-5 pearls each day. It’s also a good idea to increase your dosage just before and during travel as it often exposes you to temporary digestive and immune stress.

    Recycle your bottle when you're done. We're committed to minimizing our ecological footprint, and we'd love for you to join us by recycling your empty bottle whenever possible. In fact, we're taking action to reduce negative impacts on our planet's natural resources and improve ecosystems around the world.

    An additional tip is to eat a whole food diet, high in fruits and vegetables. Studies show that the microorganisms in our gut change relatively quickly based on the food we eat. Foods that are rich in prebiotics will also help your probiotics colonize and “set up shop” in your GI tract. Make sure to stay hydrated and to stay as active as you can so that your body can move out the unnecessary as your probiotic colonies are being repopulated.

  • What strains are in PRO-15?
    PRO-15 contains the following probiotic strains:
    • Lactobacillus plantarum
    • Lactobacillus fermentum
    • Lactobacillus acidophilus
    • Bifidobacterium infantis
    • Lactobacillus casei
    • Bifidobacterium longum
    • Lactobacillus rhamnosus
    • Bifidobacterium lactis
    • Lactobacillus reuteri
    • Lactobacillus salivarius
    • Lactobacillus paracasei
    • Lactobacillus gasseri
    • Bifidobacterium bifidum
    • Bifidobacterium breve
    • Streptococcus thermophilus

    What are the benefits of taking probiotics?
    Probiotics replenish the good bacteria in your gut and help keep you healthy by:
    • Aiding in digestion
    • Helping you absorb the nutrients from your food and vitamins
    • Supporting your immune system
    • Supporting your energy levels
    • Supporting brain function and mental clarity
    • Supporting your weight management

    What makes Hyperbiotics probiotics premium?
    Our formulas meet these four criteria:
    • Survival on the shelf
    • Survival past stomach acid
    • The right strains (human resident strains as opposed to SBOs or active yeasts)
    • A variety of strains

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    What makes Hyperbiotics probiotic formulas unique?
    We use a patented time-release delivery method called BIO-tract® that protects the beneficial organisms from stomach acids so they make it deep within your intestinal tract alive, where they can set up shop and get to work at keeping you healthy. This delivery method also ensures that our formulas have 15x more survivability than veggie capsules and powders, allowing you to finally experience the benefits that probiotics have to offer.

    How quickly can I expect to feel a difference?
    Probiotics are much like vitamins, some people notice a difference almost immediately while others may need a few weeks or more. It’s also possible to simply notice a subtle shift in a healthier direction. From the day you start taking PRO-15, it gets to work colonizing in your digestive tract.

    How long should I take a probiotic?
    We believe that taking a probiotic on a daily basis is one of the most proactive things that you can do to support your immune and digestive health. Because aspects of modern life can continuously deplete the beneficial bacteria in the gut, we suggest taking probiotics daily over the course of several months or more.

    Do I need to refrigerate these?
    With patented LiveBac®, we are able to guarantee our formulas with zero refrigerationso you can be confident that your probiotics are viable when you take them.

    Will my probiotics survive being shipped in the heat?
    Yes! LiveBac® enables our products to withstand extreme heat for up to seven dayseven longer if both seals are left intact.

    Need help understanding the microbiome?
    Check out our Microbiome Glossary to learn more about this world beneath the microscope.

    Have additional questions? We’ve got answers! View our complete FAQ list here!

  • • U.S. orders: We offer FREE standard shipping on all U.S. orders over $39, which takes 3-8 business days for order processing and shipping. We also offer FREE expedited shipping for orders over $100. Expedited shipping takes 2-6 business days for order processing and shipping.
    If your order is less than $39, you may choose standard shipping for $5 or expedited shipping for $8. 

    • International Orders (outside of the USA): We offer a flat fee of $9 for a fully-tracked shipping method to the countries listed below. For countries not on the list, we can ship via an untrackable shipping method for $9.50.
    Please note we are not responsible for duties, taxes, or customs clearance in your country.
    Please check your local requirements before placing your order.

    Czech Republic
    New Zealand
    Saudi Arabia
    South Korea
    United Arab Emirates
    United Kingdom
  • "They really did feel like they made a difference compared to other probiotic supplements I've tried. Felt more regular and less stomach discomfort without changing any other dietary habits. Definitely worth a try if you have stomach issues and tried other supplements but felt little difference. I also like the little "pill" since I sometimes find it harder to swallow capsules." - SJ

    "I've been taking it for about a month and I have noticed a significant difference in my energy level during the day and I'm sleeping better. I like it so much, I added it to my monthly auto-ship order." - Amazon Customer

    "I am loving this product! Due to assorted demands on my time, I have had only 5 or 6 hours of sleep per night for over two weeks now, and still have been able to maintain my energy and health. Normally I would be a complete mess by now. The only thing that I am doing different, and thus the only explanation that I can give, is that I had just started taking this product twice a day. It's miraculous. Hopefully I will be able to get back to a normal sleep schedule soon, but meanwhile I am overjoyed to know that I can still function under stress with Pro-15. Great product! Thank you!" - Amazon Customer

    "I have now been taking for about 15 days and this is by far the best probiotic for me. Everyone is different and I have tried at least 12-14 other brands with some being more effective than others, but nothing as good as this. This will be my go to brand for probiotics from here out." - Amazon Customer

    "Very pleased with this product. I had not been able to eat gluten wheat products for a year. I took this probiotic for a month and the following month noticed that I wasn't becoming bloated after every meal. I experimented by eating foods that previously caused severe bloating and found that they didn't have that effect anymore. I did not take anymore after the first month, but after a few months noticed some symptoms returning and have begun to take these probiotics again. I have also recommended this brand to friends and they've also reported very good effect with it. Would continue to use this product and highly recommend it to others.

    "I am an 85 yr. old female who has been searching for an effective probiotic since I suffer from chronic constipation due to necessary medications. And this IS IT."  - Amazon Customer

    "It seems like I have tried everything--numerous brands of probiotics, exercise, stress reduction techniques, you name it. In addition to feeling crummy much of the time, I could never predict the stomach bloating. As an active person who is physically fit, I mostly wear loose fitting clothes because of the bloating. Finally, I found Hyperbiotics Probiotics and life is incredible. After reading about the process behind Hyperbiotics Probiotics I decided to give it a try. After just a few days, I have NEVER felt better--no more bloating and I feel great. At first I thought the results would be short lived, but after a month I couldn't be happier." -Connie W.

    "I was actually deeply surprised at how well and how quickly this product worked. Resolved digestive issues following a long bout of antibiotics - and with that resolution came better energy, better mood, better skin. I was seriously skeptical of such broad claims; imagine my surprise when I find them to be valid, especially after trying other brands of probiotic without appreciable results. I couldn't be happier to be proved wrong." - Amazon Customer

    "This is the only probiotic I'll ever use. I have a very sensitive stomach that usually always gives me problems but taking this has helped in so many ways, no longer feel or look bloated, no gas, and no more pain when food is digesting. I've taken other probiotics but this one out shines them all." - Alli

    "I have been going thru various probiotics for a long time now, at least 4 different brands in the last 2.5 years. This works wonderfully and I was surprised at how quickly it started too. This is my third order. I waited until I had tried it for a few months before I decided to comment on its effect. It started working pretty quickly. I started taking one in the morning and one in the afternoon and things started improving, if you know what I mean. I then switched to two in the morning, on an empty stomach, and things got very well indeed. I will never give up this product." - Richard B.

    "I just got this product this month. I noticed a change by the third day. By seventh day I no longer had any abdominal distress. I have normal digestive health back after decades of struggling. I could not be happier with my decision to try this little pill.

    "It must be true what they say about it surviving the stomach and it's acids (reason it is so hard and compact), to then dissolve in gut and regulate your bowel." - S.Y. Townsend

    "Just my personal experience. If there is a miracle pill then this is the one. Had digestion problems for years. Finally decided to try probiotics and purchased this product. Started with 2 pills a day - one in the morning and one in the afternoon. I started seeing very positive results within 3-4 days and I didn't change my diet. I continue taking 2 pills a day for about a month now. And just purchased 2 more bottles of this product." - NJ Vlad

    "So far so good. Because of lifelong issues I have unfortunately had to practically live on antibiotics and I love the ease of taking these for my insides and even my skin. I feel better. Thank you! I'm sure I will be recommending it to others and continue using it." - Kathleen D.

    "Your product has helped me so much. I'm a customer for life. I even turned some people at my job on to PRO-15 and they are loving it. I believe everyone should know about great products especially those that help change people's lives. Thank you again." - Brian S.

    "Thank you all for making such a great product that REALLY WORKS!! I don't feel super tired anymore and my thoughts are much clearer. I thank you all for being a company that truly cares about the well being of others and sharing that care by making a product that helps to repair the daily damage that we do to our precious bodies.

    "Every chance I get, I will spread the word about how awesome your probiotic is. I wish you all continued success!" - Donella H.

    "We have been purchasing the PRO-15 probiotics for about a year and a half now. They work great for my wife's challenging digestive issue. Your product has been nothing short of spectacular for her. We went from her having issues almost daily, to once a month if that much. An extra pill calms the issue almost immediately." - Dawn C.

    "I have had an array of stomach issues for as long as I can remember. After 4 days of using PRO-15 my symptoms started to go away and about a week into using it I said to my husband, "do you realize I haven't complained about my stomach in almost a week!"...life changing. I was suffering from insomnia and now I'm also sleeping through the night again! I mean it's been wonderful." - Mia Lyttle

    "I love my Hyperbiotics! I was having tummy issues for awhile- typically a growling, exploding tummy in the afternoons after lunch. After a couple of weeks taking one daily pill, my issues cleared up. I've now been taking them for about 2 years, and I'm convinced that they keep my tummy much happier than it was before. If I'm feeling out of sorts, I'll take two pills in the morning instead of 1." - Eshell

    "This product changed my life. I take one in the morning and one at night. No more distress. I had bloating so bad there were times I could not catch my breath. It would go on for hours. I feel better all the way around. I am a believer. I would recommend Hyperbiotics for anyone who wants to feel good." - CR Fadden

    "Not every body is the same, but within 2 days this probiotic relieved all my issues with bloating and gas. I could never eat a big salad and then just go about my day... it was always something I'd have to eat late in the day knowing I'd be home the rest of the evening. I just wish I tried this sooner. I was having persistent bloating issues with or without eating a lot of vegetables. Not only does bloating make you uncomfortable in your own skin (and clothes), but it really affects your quality-of-life and willingness to want to go anywhere or do anything. I've taken other quality probiotics before, but this was the only one that truly worked for me." - LK

    "I have been experimenting with probiotics for several years and although I hoped they made a difference, it was just faith. Then at the recommendation of a friend I tried PRO-15 and immediately felt the difference. More energy, no bloating, no gas, no indigestion. More importantly they don't require refrigeration and this is important because I travel constantly and can take it with me. I thought it was just a fluke but it is still working 6 months later. I am sticking with this and love it." - Dallas

    "I can't believe how great this works! I read the reviews, wondering if you could possibly see a change in the way your body reacts to a probiotic so quickly. ( That had never been my experience in the past.) However, I must say I could tell a difference within a couple of days- no more bloated feeling, less gas, and less heartburn. After using it almost three weeks now, I can see even more difference. I am just getting ready to order my second bottle. This is a keeper!!!!" - M. Judy

    "I really like these. I have been taking probiotics for years now following the recommendation of my naturopathic doctor and they had helped me so much initially that I stuck with them. Ever since my health had improved, though, I had never noticed a difference in energy or gut feeling no matter what brand I purchased...until these. They don't need refrigerated like most and are less expensive. Can't beat it!" - Nathan


    We are dedicated to you and your journey toward greater health.
    We expect you will love our formulas. If for some reason you don’t, you are protected by our no-questions-asked, money back guarantee!

    Our 100% Money Back Guarantee
    We will go above and beyond to help you however we can. Just say the word if you’re not fully satisfied—for any reason—and we’ll replace your bottle for another formula or we’ll fully refund your purchase. No questions asked.

    You have everything to gain and absolutely nothing to lose.

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4.8 Based on 23 Reviews
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Julie M.
United States United States
Thank you

Very good. Had trouble with shipping, but you made it right. Great product.

E K.
United States United States
PRO 15

Very satisfied with the effects of the Pro 15 probiotics pearl!

William L.
United States United States
Every morning

I've been buying this for many years now. I first starting purchasing at Target and when Target stopped carrying it I continued directly with the company. I take one every morning and I feel like it might have stopped many colds and flues over the years.

Margo H.
United States United States
All you can ask for

Great product. I'm on a long term medically required antibiotic regimin, and have been taking 2 of these daily, along with probiotics foods. Have never had a problem from the antibiotics, and feel great. This is now my lifetime probiotic.