Time Released Pearls, Uniquely Formulated to Repopulate Your Gut

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  • GET 15 TIMES MORE RESULTS THAN WITH CAPSULES. With a superior patented delivery method, the probiotic organisms in this formula are released over an 8-10 hour period so they bypass your stomach acids and reach deep into your intestinal tract alive (where they are needed most) so you can finally experience the full benefits that probiotics have to offer.

    STAY WELL. 80% of your immune system is in your gut, and when probiotics (the good guys) are abundant in your body, it becomes harder for the bad guys to settle in. PRO-15 replenishes beneficial bacteria for optimal digestive and immune health, helps balance yeast growth, and promotes daily relief from gas, bloating, and irregularity. Life should be easy.

    SUPPORT YOUR IDEAL BODY WEIGHT. Did you know that scientists can predict whether people are fat or thin more effectively from their bacterial makeup (90 percent accuracy) than from their genes (58 percent accuracy)? It’s true. Research has made it clear that unhealthy gut flora can undermine even the best weight loss efforts. PRO-15 will help you get your gut back into equilibrium so your waistline can follow.

    LIFT YOUR MOOD AND ENERGY LEVELS. Fatigue and irritability are often a result of poor vitamin and mineral absorption. PRO-15 helps create a microenvironment inside your digestive system that promotes full nutrient absorption so you can finally feel like your happy, energetic and vibrant self.

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    RELIEVE YOUR SENSITIVE STOMACH. Hyperbiotics PRO-15 is released at consistent levels throughout the day and throughout your Gl tract; whereas other capsules more closely resemble a bomb being dropped in your upper stomach - releasing all organisms at one time, often causing digestive upset.

  • 15 Targeted Probiotic Strains (including Lactobacillus, Bifidobacterium and Streptococcus) to effectively counter the indiscriminate effects of today's broad spectrum antibiotics and other lifestyle choices that can deplete the microbiome.

    Easy to Swallow. This tiny pearl is a fraction of the size of standard capsules. No wasted fillers, just micro-packed goodness. You’re welcome.

    Long Shelf Life & No Refrigeration Necessary. With the patented LiveBac® manufacturing process, we offer a guaranteed shelf life of 18 months from the date of manufacture. Most probiotics don't provide a date of any kind because their organisms die so quickly after being manufactured.

    Natural Probiotic Supplement. At Hyperbiotics, we don't believe in artificial. Our formulas are vegetarian, non-GMO, and free of lactose, gluten, and yeast. There is also no soy, sugar, iron, nuts, artificial flavors, artificial colors, or preservatives.

    5 Billion Colony Forming Units per BIO-tract® pearl - which is equivalent to 75 Billion CFU (colony forming units) of standard probiotic capsules!

    Naturally Derived Prebiotic included in each pearl to help feed the probiotics for increased potency and effectiveness. Prebiotics are basically fibers that encourage the growth of beneficial bacteria throughout your colon.

    Only Once per Day. That's it. Because with time-release delivery, the full benefits are being delivered deep inside your gut hour by hour.

    Made in the USA. Our probiotics are homegrown with care in Washington state, then tableted in Colorado in a facility that is GMP certified through NSF. We adhere to the strictest quality control and FDA guidelines and perform rigorous testing on every lot to ensure they are effective and as the label states.

    PRO-15 does not contain any strains that are not resident to the human gut, like Soil Based Organisms (SBOs) or active yeasts.

    The Science Behind the Superiority

    Hyperbiotics PRO-15 is 15x More Effective than Capsules.

    Our formula reaches deep into your intestinal tract alive. Others don't. Let us explain…

    Gas, bloating, irregularity, weakened immune system, malabsorption of nutrients, yeast growth and other health and digestive problems affect many of us on a regular basis.

    Probiotics help restore the beneficial gut bacteria that may have been depleted as a result of poor diet, the overuse of antibiotics, food poisoning or environmental toxins, and promote overall health and well-being.

    However, studies show that without protection most probiotics entering the stomach won’t survive to reach optimal sites within the gastrointestinal tract. Most powders, liquids, capsules and even cultured dairy products retain only 4% of these sensitive organisms during passage through the stomach’s harsh environment. The good news: with the patented BIO-tract® protection and time-release delivery, we have increased this number to a remarkable 60%.

    The BIO-tract® Difference

    When the tablet is moistened by gastric fluids, a gel matrix forms that creates a protective layer, shielding beneficial organisms from stomach acids and directing them to release later in their journey.

    Once inside the gastrointestinal tract, probiotics begin to release at consistent levels from the tablet core, delivering a potent percentage of our living organisms throughout the day and throughout your gut, traveling deep into your intestinal tract where they are needed most.

    This is the only controlled-release delivery available for probiotics on the market today and is patented in 31 countries (US Patent 8,007,777 and 7,150,623).

    Finally, you can experience the full benefits that probiotics have to offer!

    BIO-tract® vs. Enteric Coated and Veggie Capsules

    Most probiotic supplements are in veggie capsules which offer no protection from a harsh stomach environment, meaning that many of the beneficial organisms do not survive long enough to deliver any benefit.

    Enteric coated probiotic capsules offer some protection from stomach acids with a few drawbacks. Most enteric coatings are made of a synthetic chemical that the capsule is then dipped into. In addition to unwanted added chemicals, the capsule contains air and the coating contains moisture that is detrimental to the probiotic organisms. You see, freeze-dried probiotic powder is ‘hygroscopic,’ meaning that it seeks out moisture. The beneficial flora will start wicking the moisture away from the air and the coating, which starts killing the living probiotics inside. Essentially, both veggie capsules and enteric coated capsules cause the living organisms inside to self-destruct, leading to a far less potent product.

    Instead of a coating or a capsule, we tablet our formulas using a patented manufacturing process called LiveBac® and a patented delivery method called BIO-tract®, which provide much better protection for the beneficial flora while on the shelf (as there is minimal air and moisture) and as the tablet travels through the harsh environment of your stomach acids. Simply put, this leads to a much more effective probiotic and exponentially greater health benefits for you. Furthermore, BIO-tract® ensures that the active organisms are released slowly over an 8-10 hour period while making the journey through the intestinal tract, successfully bypassing your stomach acids so that they can colonize in your small and large intestine, where you need them.

    Hyperbiotics formulas are naturally derived with a guaranteed shelf life of 18 months from the date of manufacture.

    † At the time of manufacture.

    ‡ Patented BIO-tract® delivery technology consistently delivers as many as 15 times, or more, the number of live, viable probiotic organisms past simulated stomach acids than (plain/standard) capsules as repeatedly demonstrated through in vitro lab testing.

  • A shelf life you can count on. We use a patented manufacturing process called LiveBac® that increases the stability of PRO-15 without refrigeration and enables us to guarantee its shelf life until the date of expiration found on the bottom of your bottle.

    Store in a cool, dry place. Really. If you don’t live in a cool, dry place, it is best to store your bottle in the fridge or even better, in the freezer, when you can. This applies to any probiotic product – especially those in capsules or blister packs. With PRO-15, we guarantee the shelf life of our product with zero refrigeration – but, as a general rule, you will maximize the potency of any probiotic product by storing appropriately. And we are all about delivering the maximum effect!

    It’s OK to take on an empty stomach (though not required). Our patented BIO-tract® delivery process ensures that the vitamins and living organisms are delivered throughout your day and throughout your GI tract – so you don’t need to buffer it with food as you may with other capsules.

    Use earlier rather than later. The reason we never have too many tablets per bottle at Hyperbiotics is that CFUs begin to slowly die off once the bottle is opened (this applies to all probiotics, not just PRO-15. In fact, our patented technology makes our die-off drastically slower than that of others!). We want you to get the highest potency possible so we simply don't pack hundreds of tablets into one bottle.

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    Increase your dosage when needed. If you are in search of more intense support or have just completed a round of antibiotics, you can take 3-5 pearls each day. It’s also a good idea to increase your dosage just before and during travel as it often exposes you to temporary digestive and immune stress.

    Recycle your bottle when you're done. We're committed to minimizing our ecological footprint, and we'd love for you to join us by recycling your empty bottle whenever possible. In fact, we're taking action to reduce negative impacts on our planet's natural resources and improve ecosystems around the world.

    An additional tip is to eat a whole food diet, high in fruits and vegetables. Studies show that the microorganisms in our gut change relatively quickly based on the food we eat. Foods that are rich in prebiotics will also help your probiotics colonize and “set up shop” in your GI tract. Make sure to stay hydrated and to stay as active as you can so that your body can move out the unnecessary as your probiotic colonies are being repopulated.

  • What strains are in PRO-15?
    PRO-15 contains the following probiotic strains:
    • Lactobacillus plantarum
    • Lactobacillus fermentum
    • Lactobacillus acidophilus
    • Bifidobacterium infantis
    • Lactobacillus casei
    • Bifidobacterium longum
    • Lactobacillus rhamnosus
    • Bifidobacterium lactis
    • Lactobacillus reuteri
    • Lactobacillus salivarius
    • Lactobacillus paracasei
    • Lactobacillus gasseri
    • Bifidobacterium bifidum
    • Bifidobacterium breve
    • Streptococcus thermophilus

    What are the benefits of taking probiotics?
    Probiotics replenish the good bacteria in your gut and help keep you healthy by:
    • Aiding in digestion
    • Helping you absorb the nutrients from your food and vitamins
    • Strengthening your immune system
    • Increasing your energy levels
    • Supporting brain function and mental clarity
    • Promoting optimal body weight

    What makes Hyperbiotics probiotics more effective?
    Our formulas deliver superior results because they meet these four criteria:
    • Survival on the shelf
    • Survival past stomach acid
    • The right strains (human resident strains as opposed to SBOs or active yeasts)
    • A variety of strains

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    What makes Hyperbiotics probiotic formulas unique?
    We use a patented time-release delivery method called BIO-tract® that protects the beneficial organisms from stomach acids so they make it deep within your intestinal tract alive, where they can set up shop and get to work at keeping you healthy. This delivery method also makes our formulas 15 times more effective than standard capsules and powders, allowing you to finally experience the full benefits that probiotics have to offer.

    How quickly can I expect to feel a difference?
    Probiotics are much like vitamins, some people notice a difference almost immediately while others may need a few weeks or more. It’s also possible to simply notice a subtle shift in a healthier direction. From the day you start taking PRO-15, it gets work colonizing and restoring balance in your digestive tract.

    How long should I take a probiotic?
    We believe that taking a probiotic on a daily basis is one of the most proactive things that you can do to support your immune and digestive health. Because aspects of modern life can continuously deplete the beneficial bacteria in the gut, we suggest taking probiotics daily over the course of several months or more.

    Do I need to refrigerate these?
    With patented LiveBac®, we are able to guarantee our formulas with zero refrigeration - so you can be confident that your probiotics are both potent and effective when you take them.

    Will my probiotics survive being shipped in the heat?
    Yes! LiveBac® enables our products to withstand extreme heat for up to seven days – even longer if both seals are left intact.

    Need help understanding the microbiome?
    Check out our Microbiome Glossary to learn more about this world beneath the microscope.

    Have additional questions? We’ve got answers! View our complete FAQ list here!

  • US Orders: Most orders within the USA ship within 1 business day via USPS.

    • Standard shipping is $3 and generally arrives within 2-7 business days.

    • Expedited shipping is $6 and generally arrives within 1-3 business days.

    • We offer FREE standard shipping on all US orders over $45.

    International Orders: (outside of the USA), we offer a flat fee of $10 to the countries listed below. For countries not on the list, we can ship via USPS or DHL and the cost varies by country. Please note we are not responsible for customs clearance in your country. Please check your local requirements before placing your order.

    Great Britain
    New Zealand

    We offer a 100% Satisfaction Guarantee or your money back!

  • "I am a long time user of your product PRO-15 (2 years now.) When I was choosing a probiotic to take I had no idea what I was looking for. I chose your product because it was the best selling product on Amazon and also because it had the most probiotics: 15 Billion. I figure more is better. All I know now is that I can contest your product actually does work. I haven't had anymore intestinal issues. It works and I will continue using it. I only wish it was a little more affordable. But as long as they keep me healthy I will keep using them at there cost. Thanks again for your product. It really does work!" - Philip W.

    "The public needs to be educated. I was a nurse and promoted probiotics after antibiotics back in the 80's and before. So much more research has been done since then, yet so many do not take them as they should. Thank you for such a great product and a great customer care team! God bless you and your business!" - Patricia B.

    "I've tried many probiotics over the years from many different companies. Few have shown the dedication to quality and customer satisfaction that Hyperbiotics has. Not only do they deliver a well made and effective probiotic with their PRO-15, they stand behind it 100% and have gone above and beyond in working with me to meet my health goals and needs." - Nathan

    "These are the best. I've tried several brands before, but now I recommend these to all my friends! I'm convinced yours is the best product I've tried!" - Ron

    "Winter is just around the corner for me and I'm getting ready and looking forward to not getting sick this year...I love fall and winter my 2 favorite seasons and with me taking Hyperbiotics I should be good to go. Thanks so much this product has helped me tremendously." - Marcelle S.

    "I'll just tell you how PRO-15 has changed my life. I've had issues with bloating and constipation for about 2 years. When I found PRO-15 on Amazon, I was skeptical. It arrived and I started with three a day for the first 10 days or so. Omg. It wasn't like other things I tried that just gave me diarrhea. I could FEEL the difference. I was regular. My skin cleared up. My hair started to grow. And I mean my poop was amazing lol. It sounds gross, but I could SEE the previously impacted poop leaving my body. I could see the bad stuff leaving. My bloating? Non existent. I recommend it to everyone that complains about any type of gut issue. Thank you for having an amazing product. You have a customer for life." - Dionysia M.

    "I have been going through various probiotics for a long time now, at least 4 different brands in the last 2.5 years. This works wonderfully and I was surprised at how quickly it started too. This is my third order. I waited until I had tried it for a few months before I decided to comment on its effect. It started working pretty quickly. I started taking one in the morning and one in the afternoon and things started improving, if you know what I mean. I then switched to two in the morning, on an empty stomach, and things got very well indeed. I will never give up this product." - Richard B.

    "Just my personal experience. If there is a miracle pill then this is the one. Had digestion problems for years. Finally decided to try probiotics and purchased this product. Started with 2 pills a day - one in the morning and one in the afternoon. I started seeing very positive results within 3-4 days and I didn't change my diet. I continue taking 2 pills a day for about a month now. And just purchased 2 more bottles of this product." - Amazon Customer

    "I feel that this product has really helped me to feel better. I started taking this along with several other supplements last month, and the difference is noticeable. I have more energy and I just generally feel better. I have definitely had a decrease in discomfort in the gut area. I'll be buying these again. They're no bigger than a green pea so they're easy to swallow. There's no bad taste and I never had an adjustment period where I had an upset stomach or anything like that. I definitely recommend these!" - M. Knight

    "I don't usually write reviews but this one is warranted. Probably the best investment you could make on your body, especially if you are experiencing digestive issues like bloating, gas, or diarrhea.

    "I started using this on May 7, 2016. Prior to that, I had a terrible history of terrible gas to the point where it was socially debilitating. It was rancid, man. I mean these farts could make your eyes water. Luckily my girlfriend loved me for who I am because anyone else would've left as soon as possible. This would happen at least 3 days a week. I read up on probiotics and saw nothing but good reviews and recommendations from doctors, so I thought what the hey. I would enjoy not obliterating my olfactory system everyday. So I bought these.

    "These were Amazon's bestseller, and had great reviews, so I went with this product, but I'm sure 90% of the probiotics out there will get you with some kind of benefits. This particular bottle was easy to swallow and doesn't require refridgeration. I take one a day, and I'm about to buy another bottle.

    "It takes about 3 weeks to change the culture of your gut, so I've heard, so don't expect it to cure you of your terrible farts and whatnot so fast. Definitely worth the time and investment though. My gut has never felt so healthy." - Amazon Customer

    "This is a great product. I've been exercising for years (avid runner and gym rat). I've always had a problem with my gut (muffin top) even though the rest of my body was in great physical shape. I didn't know if it was because of bloating but I read that this would help with that...omg I've been taking this for about a month and have already seen a great improvement! Thanks!" - Chris H.

    "I love my Hyperbiotics! I was having tummy issues for awhile- typically a growling, exploding tummy in the afternoons after lunch. After a couple of weeks taking one daily pill, my issues cleared up. I've now been taking them for about 2 years, and I'm convinced that they keep my tummy much happier than it was before. If I'm feeling out of sorts, I'll take two pills in the morning instead of 1." - Amazon Customer

    "I've tried many different probiotics. Hyperbiotics is by far the best. Both my wife and I have been taking this probiotic for a year now and the difference is amazing." - J. Gibbons

    "Okay, let me just say, for me to post a review after only 3 days says a lot about the product. So I'll start by telling you for the past month I had no energy whatsoever. My alarm will go off and it would take me at least another 20 min before getting out of bed. My body felt so drained, I had no energy. Than there's the gas and bloating I've been suffering from. It seems everything I ate sent me to the bathroom. This had become so frustrating. I didn't want to go anywhere other than work. I wouldn't eat when I was out. I just felt lousy. I did a little research and figured it was time to detox. After searching online for 2 days I decided on PRO-15. Day 1: Before eating I decided to wait for the mailman to deliver my package. When it arrived I took one while eating and immediately felt the difference. I did not have to use the bathroom and my stomach felt better. Day 2: I was up bright and early, felt like my old self, gas gone, blotting gone, able to keep my food in and so much energy, even for Day 3: Good ol' Monday morning...I actually beat my alarm by 20 min. I am a believer and will tell everyone suffering from the same problems, do not hesitate. Buy PRO-15 Hyperbiotics Probiotics." - Brooklyn

    "Love this product! After traveling quite a bit in the last month (eating differently than I normally do and suffering the gastrointestinal consequences) it's taken only a few days to feel like myself again, if you get my drift." :) - Amazon Customer

    "I have taken many different brands of probiotics and this product is by far the best that I have found at the best price! Works great and I can tell when I don't take it." - CH

    "How's this for a field test: In 7 days I traveled 17,000 miles across six time zones for work and didn't get sick. Both my coworkers who made a similar journey came back horribly ill. I took PRO-15 and Immune daily. Hyperbiotics, you have a customer for life." - Melissa

    "This is the only probiotic I'll ever use. I have a very sensitive stomach that usually always gives me problems but taking this has helped in so many ways, no longer feel or look bloated, no gas, and no more pain when food is digesting. I've taken other probiotics but this one out shines them all." - Aili

    "I love love love these probiotics! I was referred by a friend and I started using them while I was getting off of refined sugars and flour. My digestion has become very easy and my stomach much flatter since using them. I had so much less bloat and more energy after the first 2 weeks of using them! Occasionally I will splurge and eat things my body doesn't really like, so I keep some in my purse and pop 2 with the meal I think may upset my stomach and have no problems. Once I tried after the fact when I was feeling bloated and it still helped! I'm very happy with this product and I now recommend them to my friends and family." - Francesca D.

    "It absolutely blows my mind how one tiny pill a day has changed my life. I have tried other probiotics from other companies with little to no change. This one here has solved my day to day digestive issues. Amazing product." - Dan H.

    "A miracle! This hyper-biotic is a bad breath killer. I highly recommend it if you, like me, have this very embarassing issue." - Amazon Customer

    "I really love this probiotic. I've taken a dozen or more different brands over the years and none have really impressed me or delivered consistent, noticeable results. Right from the start of taking this I saw an immediate improvement in my digestion and have continued to receive the same benefits. I definitely plan on continuing to take this. It is the only probiotic that has delivered true results consistently. I highly recommend you give this a chance to show you the same amazing improvements. One bottle is all it will take to get you hooked for life." - Grace

    "Since using this probiotic, I've noticed a big difference in my gut health. At first, I didn't notice much of a change and, frankly, thought this wasn't worth my time or money. So, I stopped taking it. Very quickly after stopping, my GI tract became erratic and irritable. I, also, began to get sick frequently. I went out on a limb, bought another bottle, and within around a week things began to settle and line out. I'm a fan and have referred several of my friends/family to this probiotic!" - Amazon Customer

    "This is the best probiotic I've used. It has a wider variety of beneficial bacteria than others. Before using Pro-15, I used a "pearl" variety and one other popular brand. I notice the most difference with Pro-15. During the first two weeks taking it, I actually felt worse, but afterward I felt much better. I did some research and learned that as the probiotic is doing its work at first, it can be uncomfortable, but it's actually a sign that it's working. I feel much better with Pro-15, so much so that my husband started taking it, too, and also feels better." - P. Doyle

    "I was actually deeply surprised at how well and how quickly this product worked. Resolved digestive issues following a long bout of antibiotics - and with that resolution came better energy, better mood, better skin. I was seriously skeptical of such broad claims; imagine my surprise when I find them to be valid, especially after trying other brands of probiotic without appreciable results. I couldn't be happier to be proved wrong." - Amazon Customer

    "Sick of feeling bloated or gassy? This product is the best probiotic I've ever tried. After about two weeks I noticed I wasn't so bloated, going to the bathroom is much "easier" and often and barely any embarrassing gas. I started with three per day to get my gut back to health and now I take one per day. Will definitely continue to buy this product to maintain my digestive system. I may also try the higher dose for a month." - Matthew S.

    To read more of what our customers have to say, please visit our testimonial page!


    We are dedicated to you and your journey toward greater health.
    We expect you will love our formulas. If for some reason you don’t, you are protected by our no-questions-asked, money back guarantee!

    Our 100% Money Back Guarantee
    We will go above and beyond to help you however we can - and just say the word if you’re not fully satisfied –for any reason– and we’ll replace your bottle for another formula or we’ll fully refund your purchase. No questions asked.

    You have everything to gain and absolutely nothing to lose.

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